(Cambridge (MA.): At the University Press by Hilliard & Metcalf, 1805).

A VERY EARLY AMERICAN LECTURE ON THE DANGERS OF TOBACCO USE. Waterhouse claims smoking is a custom to be abandoned "lest you pierce with anguish the hearts of your affectionate parents!"
Benjamin Waterhouse was a cofounder of the Harvard Medical School and a prominent physician best known now for being the first doctor to test the smallpox vaccine in the United States. Waterhouse had a tendency to become involved in controversy, and exposing the evils of tobacco use was no doubt unpopular at a time it was one of the young nation's largest exports and cash-crops.
This copy with excellent medical provenance, being from the collection of American Cardiologist Myron Prinzmetal, author of at least 165 publications over the course of his career and the first to describe Prinzmetal angina. Item #30643

Scarce First Edition. 8vo, stitch-bound in the publisher's original blue paper wrappers, of which only the rear wrapper remains. Housed within a folding cloth covered chemise within a cloth-covered slipcase. 32 pp. A fine survival with age evidence as one would expect for this small and delicate pamphlet, the paper toned and with some occasional spotting, a few marginal marks, the lower corner a bit dog-eared, the lower cover a bit age spotted and edge worn, the upper wanting.